Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis.
نویسندگان
چکیده
Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.
منابع مشابه
Enantioselective synthesis of 5-epi-citreoviral using ruthenium-catalyzed asymmetric ring-closing metathesis.
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عنوان ژورنال:
- Chemical communications
دوره 51 18 شماره
صفحات -
تاریخ انتشار 2015